Dr. Guan, dedicated to the brain network mechanism and early identification of cognitive impairment, cognitive behavior training and neural regulation based on brain network and neuroplasticity. Presided over 2 general projects of the National Natural Science Foundation of China / 7 other research projects, and won 20 various achievement awards, as the first or corresponding author Cerebral Cortex, Frontiers in Aging Neuroscience, Journal of Alzheimer's Disease and other international and domestic academic 78 papers have been published in journals. Authorized 1 national patent for invention, and published 15 works (including 4 chief editors and 6 associate editors).