孙义民

兼职研究员

孙义民，生物芯片北京国家工程研究中心健康科学研究院院长，清华大学医学院和清华大学深圳研究生院特聘研究员。兼任中国医疗保健国际交流促进会常务理事，北京医学会医学细胞生物学会常委，中国医药生物技术协会生物芯片分会委员，中国医药生物技术协会精准医疗分会委员。孙义民的主要研究方向为复杂性疾病的遗传学研究，国际上首次发现中国人群非综合症型唇腭裂的特异性位点，总计发表SCI论文30余篇，其中以第一作者或通讯作者身份发表SCI论文16篇，授权发明专利7项。主持完成卫生部科技重大专项1项，国家科技支撑计划子课题1项，科技部“863”重点项目子课题1项，国家自然科学基金青年基金1项，主持在研973课题1项。参与完成的“系统化生物芯片和相关仪器设备的研制及应用“获得2006年度教育部科技成果奖，2007年度“北京市科学技术奖二等奖“及”国家技术发明奖二等奖“。

代表性论文:

  1. Xu M, Lv X, Xie L, Huang X, Huang Y, Chen Y, Peng K, Wang P, Wang W, Qi L, Bi Y, Sun Y, Ning G. Discrete associations of the GCKR variant with metabolic risk in a Chinese population: longitudinal change analysis. Diabetologia, 2016, 59(2):307-15.
  2. Jiang K, Sun Y, Wang C, Ji J, Li Y, et al. Genome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese. Oncotarget, 2015, 6(37):40327-36.
  3. Lu S, Jiao H, Xu J, Zheng Y, Sun Y, Chen H. Downregulation of IL6 Targeted MiR-376b May Contribute to a Positive IL6 Feedback Loop During Early Liver Regeneration in Mice. Cell Physiol Biochem., 2015, 37(1):233-42.
  4. Sun YM, Huang YQ, Yin AH, Pan YC, et al. Genome-wide association study identifies a new susceptibility locus for cleft lip with or without a cleft palate . Nature Communications, 2015, 6:6414
  5. Chen H, Xu J, Zhou Y, Gao Y, Wang G, Xia J, Huen M, Siok W, Jiang Y, Tan L, Sun Y. Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population. BMC Genet., 2015, 16(1):7.
  6. Guoqing Wang, Yuxi Zhou, Yong Gao, Huan Chen, Jiguang Xia, Junquan Xu, Michael S.Y. Huen, Wai Ting Siok, Yuyang Jiang, Li Hai Tan, Yimin Sun. Association of specific language impairment candidate genes CMIP and ATP2C2 with developmental dyslexia in Chinese population. Journal of Neurolinguistics, 2015, 33:163-171.
  7. Chen H, Lu S, Zhou J, Bai Z, Fu H, Xu X, Yang S, Jiao B, Sun Y. An integrated approach for the identification of USF1-centered transcriptional regulatory networks during liver regeneration. Biochim Biophys Acta., 2014, 1839(5):415-23.
  8. Sun Y, Gao Y, Zhou Y, Chen H, Wang G, Xu J, Xia J, Huen MS, Siok WT, Jiang Y, Tan LH. Association study of developmental dyslexia candidate genes DCDC2 and KIAA0319 in Chinese population. Am J Med Genet B Neuropsychiatr Genet., 2014, 165B(8):627-34.
  9. Chen H, Wang G, Xia J, Zhou Y, Gao Y, Xu J, Huen MS, Siok WT, Jiang Y, Tan LH, Sun Y. Stuttering candidate genes DRD2 but not SLC6A3 is associated with developmental dyslexia in Chinese population. Behav Brain Funct., 2014, 10(1):29.
  10. Zeng L, Sun Y, Xie L, Wei L, Ren Y, Zhao J, Qin W, Mitchelson K, Cheng J. Construction of a novel oligonucleotide array-based transcription factor interaction assay platform and its uses for profiling STAT1 cofactors in mouse fibroblast cells. Proteomics, 2013, 13(16):2377-85.
  11. Li T, Wang H, Sun Y, Zhao L, Gang Y, Guo X, Huang R, Yang Z, Pan Y, Wu K, Xu L, Liu Z, Fan D. Transcription factor CUTL1 is a negative regulator of drug resistance in gastric cancer. J Biol Chem., 2013, 288(6):4135-47.
  12. Zhang GJ, Li WJ, Li ZQ, Lv H, Ren YH, Ma RM, Li XH, Kang XX, Shi YY and Sun YM. Association between Paraoxonase gene (PON) and stroke in the Han Chinese Population. BMC Medical Genetics, 2013, 14:16.
  13. Guo Y, Liu H, Yang Z, Chen J, Sun Y and Ren X. Identification and characterization of miRNAome in tobacco (Nicotiana tabacum) by deep sequencing combined with microarray. Gene, 2012, 501 (1):24-32.
  14. Sun YM, Zhang Y, Zeng LQ, Wu JP, Ren AH, Wei L, Shao W, Zhao YC, Qiao JY, Zhang L, Mitchelson K and Cheng J. Broad profiling of DNA-binding transcription factor activities improves regulatory network construction in adult mouse tissues. J Proteome Res, 2008, 7(10): 4455-4464.
  15. Zhao M, Sun YM, Gao F, Wu XY, Tang JL, Yin H, Luo YQ, Bruce Richardson, and Lu QJ. RFX1 downregulation causes CD11a and CD70 overexpression in lupus CD4+ T cells. J Autoimmun, 2010, 35(1):58-69.
  16. Chen H, Sun Y, Dong R, Yang S, Pan C, Xiang D, Miao M, Jiao B. Mir-34a Is Upregulated during Liver Regeneration in Rats and Is Associated with the Suppression of Hepatocyte Proliferation. PLoS One, 2011;6(5):e20238